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Background@#According to the First National Tuberculosis (TB) Prevalence Survey in Mongolia the prevalence of bacteriologically-confirmed pulmonary TB among adults was 559.6 (95% CI: 454.5–664.7) per 100000 population in 2014–2015. This was three times as high as previously estimated. Nationwide anti-tuberculosis (TB) drug resistance survey was conducted in 1999 and 2007 in Mongolia. Share of multidrug resistant TB (MDR-TB) cases among newly notified TB cases increased from 1.0% in 1999 to 1.4% in 2007. Accordingly, we aimed to perform drug susceptibility test on strains isolated from TB Prevalence Survey and to determine the prevalence of drug resistant TB.@*Material and Methods@#All 242 MTB strains isolated from the survey TB cases were tested GenoTypeMTBDRplus test and conventional 1st line DST on solid medium. @*Result@#Conventional DST and GenoTypeMTBDRplus tests done for 93.8% (227/242) of them and 6.2% (15/242) were tested by GenoTypeMTBDRplus only. A 61.6% (95%CI 55.3-67.4) of all cases were susceptible to first line anti-TB drugs, any drug resistance and MDR-TBdetected as 38.4% (95% CI 32.5-44.7)and 9.5% (95% CI 6.4-13.9), respectively. Prevalence of MDR-TB was7.8% (95% CI 4.9-12.4) among new and 17.9% (95% CI 9.0-32.7) among previously treated cases. The 64 strains were identified as a resistant to isoniazid, 32.8% (42/64) and 65.6% (21/64) were katG, and inhAmutation, respectively. One isolate (1.6%) was mutations in both the inhAand katGgenes.The predominant mutations detected in therpoB were S531L (91.3%) among rifampicin resistant isolates and the mutation in inhAwas C–15T (100%) and katG mutation was S315T1 (100%) among isoniazid-resistant isolates. @*Conclusion@#Prevalence of cases with DR-TB is high among prevalent TB cases, especially prevalence of MDR-TB among new cases. In comparison to previous studies, DR-TB cases seem to be increased. Rifampicin resistant strains have a mutation of the rpoBand resistance to isoniazid is predominantly associated with the inhA mutation.
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BACKGROUND:Tuberculosis is still an important infectious disease today. The resent World Health Organization TB Fact Sheet statesthat it kills approximately 2 million people each year. WHO estimated that between the years 2002 and 2020 inclusive,approximately 1000 million people will be newly infected. According to the fact sheet over the same period, more than150 million people will become infected, and 36 million will be die due to tuberculosis, if control of the diseases is furthernot strengthened.1In 2009, there were registered 4218 tuberculosis new cases in Mongolia. Among them 1809 cases were smear positivepulmonary cases. Mongolia has the 7th highest tuberculosis case rate country in the WHO.WPR.2GOAL: To review “Reporting Form” of the new registered cases of tuberculosis in Mongolia (2007-2009).OBJECTIVES:1. Evaluation how correct fills out of the “Reporting Form”–s of new registered cases tuberculosis.2. Social and professionals status of tuberculosis cases in Mongolia.MATERIALS AND METHODS:We conducted a retrospective study of 10237 Reporting Form of new case of TB. Which are cases reported from 21aimags and 9 districts of Ulaanbaatar city to the Tuberculosis Department of NCCD, between 2007 and 2009.Retrospective analysis for the “line list of tempore office leave’s” among health care works in National Center forCommunicable DiseasesRESULTS:10237 (79%) out of 12802 new TB cases were correct fill out new cases Reporting Forms in 2007-2009In 2007-2009, there were 43.3 %( 4436) unemployed people, 9.7% (994) students, 8.8 %( 901) pupils, 7.0 %( 712)pensionaries of all registered cases. A total cases 18.5 percentage was students.Also 111 health care workers were developed TB throughout country and it is 1.1% of total cases. A total cases of Healthcare workers; 30.6% (34) nurses, 28 %( 31) doctors, 15.3 %( 17) house keepers, nurses are most affected TB fromhealth care workers. Doctor’s who are working in TB and the judicial department, surgeons, dentists, center to recoverthe alcoholic, soum and family practitioners are most affected compared other doctors.CONCLUSION:1. In 2007-2009, there were 43.3% unemployed people, 9.7% students, 8.8% pupils, 7.0% pensionaries, 1.1%health care workers of all registered cases.2. Excepting students TB rate is 18.5% and this rate increasing year by year. We need to more study and analysisof students TB cases and need to planning further intervention among students3. Among health care workers who are working in tuberculosis hospital more risk of get infected tuberculosis.Urgent needs to improve the infection control intervention in the TB hospital and clinics, branch offices, whichhave high risk of infection.
ABSTRACT
BACKGROUND: Tuberculosis (TB) morbidity and mortality has been one of the pressing issues in the health sector of our country. In Mongolia, 2 people out of 1000 people developed tuberculosis annually, which leads to becoming one of the 7 countries with high TB morbidity among 37 countries of the Western Pacifi c Region.OBJECTIVE: The aim of the study is to have the baseline to understand and measure knowledge, attitudes and practices regarding tuberculosis among non-tuberculosis health care workers including family group practitioners, nurses and specialized doctors at the primary, secondary and tertiary health care level of Mongolia.MATERIALS AND METHOD: Cross-sectional descriptive qualitative study. Self-admitted questionnaire were performed for 572 health care workers. Total of 4 aimags/provinces and 3 districts were randomly selected. Selenge, Darkhan-Uul, and Khentii aimags are regions with high tuberculosis burden, Dornogobi and Orkhon aimags are with low Tuberculosis incidence and prevalence in 2008.Altogether 572 doctors and health professionals from selected health facilities were involved in survey questionnaire and 39.9% (228 people) of respondents were working at the primary level, 31.3% (179 people) in secondary level, and 28.8% (165 people) in the tertiary level health facility, respectively. Altogether 23 focus group discussions were organized, involving 130 people.RESULTS: Around 98.6% of respondents answered that TB is spread when infected person coughs and sneezes. However, one of every three respondents answered TB can be transmitted when sharing cups, dishes and other cooking utensils with the infected person, one in every ten people–shaking hands with the infected person, and one in every four people–through mother to child transmission. Such misconception is common among the health professionals, especially among nurses of the secondary and tertiary level health facilities. Around 47.6% or 272 people answered correctly that TB patients have symptoms such as coughing for 2 weeks and longer, develop sputum with blood traces, fever and sweating during night sleep, and loss of weight. However, there is some misunderstanding among the doctors and nurses such as there are skin rashes. When doctors and nurses where asked which form of TB is the infectious one, 86.9% answered correctly that TB with positive smear test is infectious. On assessing the knowledge, attitude and practice on TB treatment, about 93.4% of the respondents answered that treatment shall be done by anti-TB drugs and this result is equally strong among health professionals at all service delivery levels (p=0.075). However, there are some misconceptions among the nurses that TB patients should buy anti-TB drugs from the pharmacies, try traditional medicines and follow religious rituals. This should be paid further attention and issues covering TB should be included in their curriculum. Every second person knows the treatment continuation period of drug susceptible TB patient, which is relatively low knowledge level. According to survey results, every second person knows what DOTS stand for. In other words, 55.4% of the respondents identifi ed correctly what is DOTS, and 13.8% answered that it is a combination of anti-TB drugs, 3 .3% - as TB treatment method, 5.6% - as combination of TB reduction measures, and 2.2% answered that they don’t know.CONCLUSION: Many misunderstandings were found in the fi eld of transmission, BCG vaccination, treatment and anti-TB drugs. There is a need to provide training for non-TB medical doctors and nurses.